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Base excision repair table

 

Base Excision Repair (BER)

Base Excision Repair (BER)

Step Enzyme Key Feature Analogy
Recognition and Removal of Damaged Base DNA glycosylase Specificity for certain types of damage DNA as a string of beads
AP Site Incision AP endonuclease Single-strand repair Damaged bead removal creates a gap
Endonuclease and Lyase Activity Endonuclease and lyase activity Ubiquity, always on duty Enzymes clean up the gap like a repair crew
Gap Filling and DNA Ligation DNA polymerase and DNA ligase Preservation of genetic information DNA polymerase as a bead-maker
Final Verification DNA polymerase with proofreading ability Surveillance mechanisms ensure accuracy Superheroes double-check their work
Base Excision Repair

Base Excision Repair

Process Overview
Recognition and Removal of Damaged Base
AP Site Incision
Endonuclease and Lyase Activity
Gap Filling and DNA Ligation
Final Verification
Key Features and Significance
Specificity
Single-Strand Repair
Ubiquity
Preservation of Genetic Information

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